Curzest for anti-aging

Health is wealth!!!

“Aging is not one process. Its many different things going on that cause us to age. We have a program that slows down each of these different processes.”

Ageing is an inevitable process of life. Truly speaking, ageing is not the number of the years one has existed, it is the number of changes at cellular level that makes one susceptible to diseases and infections.

Aging is a gradual complex process leading to deterioration of body function and increasing vulnerability to diseases. Wrinkled skin, age spots, greying hair, reduced muscle mass are few of the external changes aging brings about. Internally it affects one’s vision and hearing, memory, blood pressure, digestion and weakens bones and joints.

Aging is a natural process that has to happen but the key point – you should be healthy.

Curcumin is a highly plieotropic molecule. Its anti-oxidant, anti-inflammatory, anti-cancer and anti-microbial properties makes it an ideal product to delay and prevent the aging process.

 

Eyes – Prevent vision loss!

Glaucoma, cataract, age-related macular degeneration (AMD), dry eye, diabetic retinopathy and retinal detachment are few of the age related visual disorders. Curcumin plays a therapeutic role in many ophthalmologic conditions.

AMD is damage to retinal cells because of oxidative stress. Curcumin protects the retinal cells from oxidative damage and thus prevents as well as treats AMD. Anti-inflammatory properties of curcumin helps it to treat dry eye. Diabetic retinopathy, one of the most feared complications of diabetes, is effectively prevented and treated with curcumin. Curcumin reduces the mechanism that leads to rise of eye pressure and thus prevents glaucoma. The anti-inflammatory, anti-oxidant and anti-clotting properties of curcumin are responsible for the beneficial effects that help protect the eye and vision.

 

 

Skin Aging – Stay Young!

Wrinkles, loss of skin elasticity, and collagen destruction are the first visible signs of aging. More than skin deep, these degradations also are reflective of our internal aging as well. By slowing the factors that cause skin aging, we can also slow total body aging. That’s because the same basic mechanisms are at work to age us on the outside such as smoking, air pollution, poor diet and alcohol intake as well as the inside: oxidant stress, inflammation, damage to DNA, glycation, cell membrane damage, declining hormone levels and hereditary factors.

Skin is a lipid rich tissue and neutralising of free radicals, reduction of inflammation, modulation of abnormal cell growth, reduction of UV damage and the slowing of accumulation of age related pigments in the skin is essential for skin care. Curcumin protects skin by quenching free radicals and reducing inflammation through nuclear factor – kappa β inhibition.

 

Cardio Vascular System – Healthy Heart!

Elderly people suffer from coronary artery disease, hypertension and heart failure. Heart disease remains the most common cause of mortality in the elderly. With aging, there is a increase in reactive oxygen species (ROS). ROS causes oxidative stress and thus cardio vascular damage. Curcumin is a powerful anti-oxidant and scavenges the ROS and thus limits damage to the heart.

Curcumin has a positive effect on lipid profile. It leads to reduction in lipid peroxidation, plasma cholesterol and thus atherosclerotic lesions. In addition, curcumin attenuates endothelial dysfunction and thus maintains the elasticity of arteries. So much so, it can ameliorate arterial stiffening and reverse endothelial dysfunction.

 

Musculoskeletal system – Healthy bones and joints!

Bones, muscles and joint tissues weaken with age. Osteoarthritis and osteoporosis are the major diseases affecting musculoskeletal system of the elderly.

Osteoarthritis is a chronic condition of joints characterised by wear and tear and causes pain, swelling and reduced motion. Osteoporosis is a chronic condition characterized by loss of bone mass and increased risk of fractures. It generally affects postmenopausal women due to estrogen deficiency.

Curcumin has an inhibitory effect on substances involved in the inflammatory pathway, including lipoxygenase, cyclooxygenase (COX), phospholipase, collagenase, elastase, and hyaluronidase. It also inhibits the activation of free radical activated transcription factors such as nuclear factor kappa B and nitric oxide synthase. In addition, it reduces the proinflammatory cytokines: eg, tumor necrosis factor alpha, interleukin (IL)-1 beta, IL-8, and matrix metalloproteinase. All of these substances have a major role in the inflammatory joint process.

The above mentioned properties of curcumin help in prevention of osteoarthritis and osteoporosis, increases bone mineral density and keeps the joints healthy by preventing damage to cartilage. Anti-inflammatory properties of curcumin make it efficacious in treating acute and chronic joint pains and thus emerges as a safer alternative to NSAIDs. Various studies have shown it to be as efficacious as NSAIDs such as Ibuprofen and celecoxib without any side-effects.

 

Nervous system – Preserve cognitive performance!

With aging, brain shrinks and memory loss is observed. Additionally, there is decline in cognitive performance. Reduced production of neurotransmitters and hormones affect the functioning of ageing brain. Dementia, Alzheimer’s disease and stroke are the most common neurodegenerative diseases prevalent in the elderly.

Curcumin has neuroprotective action in Alzheimer’s disease, dementia, major depression and other related neuro degenerative and neuro psychiatric disorders. It exhibits these actions by exerting anti-inflammatory, antioxidant and anti-protein aggregate activity. It inhibits accumulation of amyloid bodies in the brain that are though to be responsible for ALzheimer’s disease. It reduces neurotransmitter toxicity and control oxidative stress in Parkinsons’ disease and offers protection from damage caused by stroke.

 

Prevention of cancer!

Chemoprevention, which is referred to as the use of non-toxic natural or synthetic chemicals to intervene in multistage carcinogenesis, has emerged as a promising and pragmatic medical approach to reduce the risk of cancer. Curcumin has been shown to protect against skin, prostate, breast, oral, intestinal, and colon carcinogenesis and also to suppress angiogenesis and metastasis. It also inhibits the proliferation of cancer cells by arresting them in the various phases of the cell cycle and by inducing apoptosis. Moreover, curcumin has a capability to inhibit carcinogen bioactivation via suppression of specific cytochrome P450 isozymes, as well as to induce the activity or expression of phase II carcinogen detoxifying enzymes.

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