Curzest for cancer
Curcumin is active extract of Curcuma longa and has traditionally been used for treatment of variety of medical conditions because of its strong antioxidant and anti-inflammatory properties. Curcumin is a highly pleiotropic molecule which can be a modulator of intracellular signaling pathways that control cell growth, inflammation, and apoptosis.
Anti-inflammatory, anti-oxidative, apoptosis inducing and anti-angiogenic abilities of curcumin are the main characteristics which are involved in its anti-cancer activity.
Extensive research within the last decade has revealed that curcumin can sensitize tumors to different chemotherapeutic agents including doxorubicin, 5-FU, paclitaxel, vincristine, melphalan, butyrate, cisplatin, celecoxib, vinorelbine, gemcitabine, oxaliplatin, etoposide, sulfino- sine, thalidomide, and bortezomib. Chemosensitization has been observed in cancers of the breast, colon, pancreas, gastric, liver, blood, lung, prostate, bladder, cervix, ovary, head and neck, and brain and in multiple myeloma, leukemia, and lymphoma. Studies have also revealed that curcumin can sensitize a variety of tumors to gamma radiation including glioma, neuroblastoma, cervical carcinoma, epidermal carcinoma, prostate cancer, and colon cancer.
Curcumin downregulates various growth regulatory pathways and specific genetic targets including genes for NF-κB, STAT3, COX2, Akt, antiapoptotic proteins, growth factor receptors, and multidrug-resistance proteins. Although it acts as a chemosensitizer and radiosensitizer, curcumin has also been shown to protect normal organs such as liver, kidney, oral mucosa and heart from chemotherapy and radiotherapy induced toxicity.
The protective effects of curcumin appear to be mediated through its ability to induce the activation of NRF2 and induce the expression of antioxidant enzymes (e.g. hemeoxygenase-1, glutathione peroxidase, modulatory subunit of gamma-glutamyl-cysteine ligase, and NAD(P)H:quinone oxidoreductase 1), increase glutathione, directly quench free radicals, and inhibit p300 HAT activity.
Curcumin suppresses all 3 stages of carcinogenesis: initiation, promotion, and progression and in addition to its sensitizer role, curcumin has tremendous potential in chemoprevention of cancer.
Curcumin is an ideal, safe, and highly effective compound that can be used as an adjunct in cancer therapy. The chemosensitizer and radiosensitizer effects combined with its ability to prevent depression, fatigue, neuropathic pain, lack of sleep, and lack of appetite, all symptoms that are induced by cancer and cancer treatment, make curcumin an ideal agent for cancer patients.
Anti-oxidant and Anti-inflammatory properties of Curzest help in prevention of cancer in patients who are at high risk and prevents recurrence of cancer.
All these positive effects of curcumin come without any negative effects.
How Curzest works in cancer?
- Inhibits proliferation of cancer cells by arresting them in various phases of the cell cycle and by inducing apoptosis.
- Suppresses transformation, proliferation and metastasis of tumor. Effects are mediated through regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinases and other enzymes.
- Potent anti-inflammatory agent with strong therapeutic potential against a variety of cancers including cancers of the blood, skin, oral cavity, lung, pancreas, breast, prostate, colon and other GI malignancies.
- Inhibits transformation of cells from normal to abnormal.
- Promotes anti-angiogenesis, destroys mutated cancer cells and limits spread of tumor.
- Modulates genetic activity and expression—both by destroying cancer cells and by promoting healthy cell function.