Curzest - The inflammation antidote
Curcumin is a highly pleiotropic molecule capable of interacting with numerous molecular targets involved in inflammation. Curcumin modulates the inflammatory response by down-regulating the activity of cyclooxygenase-2 (COX-2), lipoxygenase, and inducible nitric oxide synthase (iNOS) enzymes; inhibits the production of the inflammatory cytokines tumor necrosis factor-alpha (TNF-a), interleukin (IL) -1, -2, -6, -8, and -12, monocyte chemoattractant protein (MCP), and migration inhibitory protein; and down-regulates mitogen-activated and Janus kinases.
COX-2 and iNOS inhibition are accomplished via curcumin’s suppression of nuclear factorkappa B (NF-κB) activation.NF-κB, a ubiquitous eukaryotic transcription factor, is involved in regulation of inflammation, cellular proliferation, transformation, and tumorigenesis. Curcumin suppresses NF-κB activation and proinflammatory gene expression by blocking phosphorylation of inhibitory factor -kappa B kinase (IκB). Suppression of NF-κB activation subsequently down-regulates COX-2 and iNOS expression, inhibiting the inflammatory process and tumorigenesis. Curcumin also inhibits arachidonic acid metabolism and inflammation via downregulation of the cyclooxygenase and lipoxygenase pathways. Curcumin’s inhibition of inflammatory cytokines is achieved through a number of mechanisms. Curcumin regulates activation of certain transcription factors such as activating protein-1 (AP-1) and NF-κB in stimulated monocytes and alveolar macrophages, thereby blocking expression of cytokine gene expression. Down-regulation of intercellular signaling proteins, such as protein kinase C, may be another way in which curcumin inhibits cytokine production.
Chronic low-level inflammation plays a major role in almost every chronic disease. This includes heart disease, cancer, metabolic syndrome, Alzheimer’s and various degenerative conditions. Therefore, anything that can help fight chronic inflammation is of paramount importance in preventing and even treating these diseases.